Course Synopsis:

This course will provide an introduction to the fundamental ideas of the bioreactor design and operations. It will also develop students’ knowledge and understanding the important principles and techniques that are used in the design and analysis of various types of bioreactor system for microbial, animal and plant cell cultures. It also covers relevant issues in bioreactor system such as scaling up/down, instrumentation and control of bioreactor as well as sterilization. 

Course Outcomes:
Ability to design and formulate fermentation media and decide on the types of carbon and nitrogen source.
Ability to recognize, compare and draw the schematic diagram for specific types of bioreactors.
Ability to design a stirred tank bioreactor according to the specific application.
Ability to develop scale up based on geometric similarities or constant power number.


Doran, P. M. 2006. Bioprocess Engineering Principles. London: Academic Press.
Shuler, M. L. and Kargi, F. 2001. Bioprocess Engineering: Basic Concepts. 2nd Ed. Upper Saddle River, NJ: Prentice Hall PTR.
Asenjo, J. A. and Merchuk, J. A. 1995. Bioreactor System Design. New York: Marcel Dekker Inc.
Najafpour, G.A. 2007. Biochemical Engineering and Biotechnology. Amsterdam: Elsevier B.V.
Mitchell, D. A., Krieger, N. and Berovic, M. 2006. Solid-state fermentation bioreactors: Fundamentals of design and operation. Springer Berlin Heidelberg. 
Scragg, A. H. 1992. Bioreactors in Biotechnology: A Practical Approach. Ellis Horwood.
Stanbury, S.F. and Whitaker, A. 1984. Principle of Fermentation Technology. New York: Pergamon Press.